Data Science concerns with the activities of processing and analysing data in a particular domain, as well as applying machine learning algorithms to automatically discover insights and interesting patterns from the data. While data scientist needs tools to explore and visualize data, along with performing machine learning experiments and evaluating candidate models, operational platforms are required to productionize and maintain the resultant models, and integrate them into the operational systems. In this session, we explore the main features and capabilities of various Microsoft technologies that enable such end-to-end data science exercise, including SQL Server and Azure PaaS Services, along with practical scenarios and demos.